Cremello and Perlino horses have two copies of the cream gene, meaning they are homozygous for cream. The only way to breed a homozygous cream is for both parents to carry at least one copy of the cream gene ie buckskin, palomino,cremello or perlino. Breeding two homozygous creams together will always result in the foal being cremello or perlino.
There are many misconceptions regarding homozygous cream horses, for example - they are albino. This is incorrect as there has never been a documented case of an albino horse in history. There have always been myths but these most likely can be attributed to people seeing a cremello or perlino horse and just assuming it was albino. Albinos have no pigment in their skin, hair and eyes, whereas a homozygous cream horse still has pigment in these places as even when there are two copies of the cream gene present in the horse, the gene only makes the colour lighter but will not totally remove it. For example - a buckskin horse has only one copy of the cream gene on a bay base. Since These horses have no higher incidence of skin cancers -which is another fallacy - than any other coloured horse. They can still have white markings, and only on these white markings is there a lack of pigment which is no different to any other coloured horse with white markings, thus making sunburn and skin cancers no more of a risk than any other non cream horse. The cream gene is also not known to be associated with any health problems.
Homozygous creams share many characteristics and it can sometimes be very hard to distiguish between the two.They both have pigmented pink skin, blue eyes and coats of varying shades of pale cream which may appear white but is never truly white.
A cremello horse is the result of both parents carrying at least one copy of the cream gene acting on a chestnut base coat. They can have a very pale to off white coat colour right up to a richer pale palomino colour with a white or cream mane and tail. The only way to breed a cremello is to breed two parents who carry the cream gene such as palomino, buckskin, cremello or perlino. A cremello bred to any other coloured horse will result in a 100% chance of the offspring carrying the cream gene.
A perlino horse is the result of both parents carrying at least one copy of the cream gene on a bay, brown or black base coat. They have a cream coloured body generally lighter than their mane and tail which may have a reddish tinge along with their lower legs. The only way to breed a perlino is to breed two parents who carry the cream gene, and as with the cremello, a perlino bred to any other coloured horse will result in the offspring carrying the cream gene 100% of the time.